Why Does Glutathione Decline With Age? As we age, our body gradually loses some of its natural protective mechanisms. One of them is glutathione (GSH) a key antioxidant that protects Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Deficient Glutathione in the Pathophysiology of Mycotoxin Related Illness Frontiers Glutathione: A Samsonian life sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation Glutathione reductase Wikipedia